TM Bioscience Corporation
Toronto, ON
Company Overview
TM scientists have developed and patented several key technologies that relate to highly accurate DNA detection in complex multi-sequence applications. Tm has validated the application of its Ligand Controlled Hybridization (LCH) technology to biochips with a successful proof of concept achieved with Affymetrixs GeneChip. Tm has entered a strategic partnership with Drug Discovery Limited, who will supply Tm with compounds to be used in hybridization control. Several collaborative research agreements have been entered with major biotech companies including PE Biosystems. TM has recently shown that the use of its proprietary HP capture probes and SAT technology can significantly enhance detection assay performance.
Company Information
Physical Address
1050-439 University Ave.
Toronto, ON M5G 1Y8
CA
Mailing Address
1050-439 University Ave.
Toronto, ON M5G 1Y8
CA
Additional Details
Legal Name: TM Bioscience Corporation
CA
- Sequence Probe Design Engine,
The success of hybridization using oligonucleotides depends on minimizing the number of false positives and false negatives. Such problems have made the analysis of multiple gene sequences on a gene chip array very difficult. Tm Bioscience has developed a novel sequence selection method applied to probe selection that addresses this problem.
- Ligand Controlled Hybridization,
a product that addresses problems with hybridization control in various systems including biochips and multiplexing. Current technology is unable to control hybridization reaction complexity consistently and uniformly across entire arrays consisting of thousands of elements. Through the use of TMs Ligand Controlled Hybridization technology this can now be achieved.
- Signal Amplification Technology (SAT),
that provides enhanced detection sensitivity. Tm Biosciences SAT can be directly applied to existing DNA (and antibody based) assays in several areas including SNP analysis, clinical diagnostics and gene expression profiling. Incorporation of TMBs SAT is an effective means of generating a substantial increase in sensitivity (greater than 1, 000 fold) of nucleic acid detection.
- Hairpin (HP) Capture Probes,
a technology for efficient capture of nucleic acids. Single-stranded linear oligonucleotide probes are commonly used in hybridization reactions. Applications involving HP probes exhibit significantly higher rates of target capture relative to linear capture probes (up to 4x better performance). Moreover, HP probes are capable of capturing greater quantities (up to 4x more) across a large target concentration range and perform significantly better at low target concentrations relative to linear probes.
Contacts
Products
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Hairpin Capture Probe
Superior DNA probes for target capture. Single-stranded linear oligonucleotide probes are commonly used in hybridization reactions. Applications involving Hairpin (HP) probes exhibit significantly higher rates of target capture relative to linear capture probes (up to 4x better performance). Moreover, HP probes are capable of capturing greater quantities (up to 4x more) across a large target concentration range and perform significantly better at low target concentrations relative to linear probes.
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Ligand Controlled Hybridization
Hybridization control in various systems including biochips and multiplexing. Ligand Controlled Hybridization addresses problems with hybridization control in various systems including biochips and multiplexing. Current technology is unable to control hybridization reaction complexity consistently and uniformly across entire arrays consisting of thousands of elements. Through the use of TMs Ligand Controlled Hybridization technology this can now be achieved.
- Sequence Design Engine
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Signal Amplification Technology
Signal Amplification Technology (SAT) provides enhanced detection sensitivity for nucleic acids and proteins. Tm Biosciences SAT can be directly applied to existing DNA (and antibody based) assays in several areas including SNP analysis, clinical diagnostics and gene expression profiling. Incorporation of TMBs SAT is an effective means of generating a substantial increase in sensitivity (greater than 1, 000 fold) of nucleic acid detection.
Additional Information
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