TM Bioscience Corporation

TM Bioscience Corporation

TM scientists have developed and patented several key
technologies that relate to highly accurate DNA detection in
complex multi-sequence applications. Tm has validated the
application of its Ligand Controlled Hybridization (LCH)
technology to biochips with a successful proof of concept
achieved with Affymetrixs GeneChip. Tm has entered a strategic
partnership with Drug Discovery Limited, who will supply Tm with
compounds to be used in hybridization control. Several
collaborative research agreements have been entered with major
biotech companies including PE Biosystems. TM has recently shown
that the use of its proprietary HP capture probes and SAT
technology can significantly enhance detection assay performance.

Company Details

Company Information

Graham Henderson
Title: Data Provider
Telephone: (416) 593-4323
Email: Click Here

Products

Sequence Design Engine

Ligand Controlled Hybridization
Hybridization control in various systems including biochips and multiplexing. Ligand Controlled Hybridization addresses problems with hybridization control in various systems including biochips and multiplexing. Current technology is unable to control hybridization reaction complexity consistently and uniformly across entire arrays consisting of thousands of elements. Through the use of TMs Ligand Controlled Hybridization technology this can now be achieved.

Hairpin Capture Probe
Superior DNA probes for target capture. Single-stranded linear oligonucleotide probes are commonly used in hybridization reactions. Applications involving Hairpin (HP) probes exhibit significantly higher rates of target capture relative to linear capture probes (up to 4x better performance). Moreover, HP probes are capable of capturing greater quantities (up to 4x more) across a large target concentration range and perform significantly better at low target concentrations relative to linear probes.

Signal Amplification Technology
Signal Amplification Technology (SAT) provides enhanced detection sensitivity for nucleic acids and proteins. Tm Biosciences SAT can be directly applied to existing DNA (and antibody based) assays in several areas including SNP analysis, clinical diagnostics and gene expression profiling. Incorporation of TMBs SAT is an effective means of generating a substantial increase in sensitivity (greater than 1,000 fold) of nucleic acid detection.

Services